Project 1


Sickle Cell Disease Genomics Network of Africa

Research Projects (Project 1)

To determine the variation in the levels of five major haemolysis

cytoprotective proteins in SCD by studying a cohort of 7,000 patients from six cities

Ghana, Nigeria and Tanzania. To document the prevalence of acute damage to major

organs during hospitalization of SCD patients in a cohort of 7,000 SCD patients. To

catalogue genome-wide variants associated with the levels of the five haemolysis

cytoprotective in SCD patients. To provide evidence in support or against the idea that

SCD patients with higher plasma concentrations of haemolysis cytoprotective proteins

have a lower risk than age- and gender-matched counterparts in developing acute

damage to major organs during VOC and hyper hemolysis.

SickleGenAfrica is funded by NIH Common Fund Award / NHLBI Grant Number U54HL141011

The SickleGenAfrica website content is solely the responsiblity of the authors and does not necessarily represent the official views of the National Institutes of Health.


Sickle Cell Disease Genomics Network of Africa (SickleGenAfrica).

SickleGenAfrica: A research network of the H3Africa consortium

Get in Touch

Administration & Examination Hall Building.

School of Biomedical and Allied Health Sciences.

University of Ghana,

Korle Bu, Accra, Ghana

Telephone: +233 30 397 0949

Project Manager

Justina Agula, MSc

Telephone: +233 24 814 9499

© 2017 SickleGenAfrica