Project 1


Sickle Cell Disease Genomics Network of Africa

Research Projects (Project 1)

To determine the variation in the levels of five major haemolysis

cytoprotective proteins in SCD by studying a cohort of 7,000 patients from six cities

Ghana, Nigeria and Tanzania. To document the prevalence of acute damage to major

organs during hospitalization of SCD patients in a cohort of 7,000 SCD patients. To

catalogue genome-wide variants associated with the levels of the five haemolysis

cytoprotective in SCD patients. To provide evidence in support or against the idea that

SCD patients with higher plasma concentrations of haemolysis cytoprotective proteins

have a lower risk than age- and gender-matched counterparts in developing acute

damage to major organs during VOC and hyper hemolysis.


Administration & Examination Hall Building.

School of Biomedical and Allied Health Sciences.

University of Ghana,

Korle Bu, Accra, Ghana

+233 303 970949


SickleGenAfrica is funded by NIH Common Fund Award / NHLBI Grant Number U54HL141011

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