Sickle Cell Disease Genomics Network of Africa
Research Projects (Project 2)
To determine the prevalence of malaria, severe malaria anaemia, malaria
ARDS and cerebral malaria in SCD by longitudinally tracking a cohort of 7,000 patients
Catalogue genome-wide variants associated with severe malaria complications among
SCD patients.Provide observational evidence to support or refute the idea that
polymorphisms associated with levels of key haemolysis cytoprotective proteins
influence development of severe malaria among SCD patients. Provide evidence of the
inflammatory response (cytokines/chemokines and adhesion molecules) in SCD
patients with and without malaria, and determine levels of biomarkers of malaria
severity and their relationship with plasma haem levels and genetic variants that
influence haemolysis cytoprotective protein levels.
Administration & Examination Hall Building.
School of Biomedical and Allied Health Sciences.
University of Ghana,
Korle Bu, Accra, Ghana
+233 303 970949
SickleGenAfrica is funded by NIH Common Fund Award / NHLBI Grant Number U54HL141011
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