Project 2


Sickle Cell Disease Genomics Network of Africa

Research Projects (Project 2)

To determine the prevalence of malaria, severe malaria anaemia, malaria

ARDS and cerebral malaria in SCD by longitudinally tracking a cohort of 7,000 patients

Catalogue genome-wide variants associated with severe malaria complications among

SCD patients.Provide observational evidence to support or refute the idea that

polymorphisms associated with levels of key haemolysis cytoprotective proteins

influence development of severe malaria among SCD patients. Provide evidence of the

inflammatory response (cytokines/chemokines and adhesion molecules) in SCD

patients with and without malaria, and determine levels of biomarkers of malaria

severity and their relationship with plasma haem levels and genetic variants that

influence haemolysis cytoprotective protein levels.


Administration & Examination Hall Building.

School of Biomedical and Allied Health Sciences.

University of Ghana,

Korle Bu, Accra, Ghana

+233 303 970949


SickleGenAfrica is funded by NIH Common Fund Award / NHLBI Grant Number U54HL141011

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